د. محمد أحمد غطاس

نائب عميد كلية الصيدلة

مقر أبوظبي

+971 2 6133275

pharmacy_ad@aau.ac.ae

التعليم

Ph.D. Medicinal Chemistry, School of Pharmacy and Pharmaceutical Sciences, The University of Manchester, Manchester, UK

B.Pharm. Faculty of Pharmacy, Phildephia University – Amman, Jordan

الاهتمامات البحثية

My research interest lies in the field of computer-aided drug design where I focus in three main areas: (1) Designing and discovery of new inhibitors for different drug targets using structure-based and ligand-based approaches; (2) Assessing protein structures in terms of pocket protein-ligand interactions and druggability: (3) Investigating the aggregation molecular behavior of small organic molecules using molecular dynamics simulations.

منشورات مختارة

    • Ghattas MA*, Eissa NA*, Tessaro F, Perozzo R, Scapozza L, Obaid D, Atatreh N. Structure‐based drug design and in‐vitro testing reveal new inhibitors of enoyl acyl carrier protein reductases. Chemical Biology & Drug Design. Published online in May 7, 2019. https://doi.org/10.1111/cbdd.13536 * Equal contribution
    • Salem, AA, Lotfy Mb, Amin Ab, Ghattas MA. Characterization of human serum albumin's interactions with safranal and crocin using multi-spectroscopic and molecular docking techniques. Biochemistry and Biophysics Reports, 2019. https://doi.org/10.1016/j.bbrep.2019.100670
    • Atatreh N, AlRawashdah S, Al Neyadi SS, Abuhamdah SM, GhattasMA*. Discovery of new butyrylcholinesterase inhibitors via structure-based virtual screening. J of enzyme inhibition and medicinal chemistry 34, 1373-1379, 2019.https://doi.org/10.1080/14756366.2019.1644329*Corresponding author
    • Mohamed FE, Al Sorkhy M, Ghattas MA, Al-Zaabi N, Al-Shamsi A, Almansoori TM, Al-Gazali L, Al-Dirbashi OY, Al-Jasmi F, Ali BR. A Novel Homozygous Missense Variant in the NAGA Gene with Extreme Intrafamilial Phenotypic Heterogeneity, Journal of Molecular Neuroscience, 2019. https://doi.org/10.1007/s12031-019-01398-6
    • Al Rawashdah S, Hamrouni A, Sadek B, Amer R, Metwaly M, Atatreh N, Ghattas MA. Molecular modelling studies on ɑ7 nicotinic receptor allosteric modulators yields novel filter-based virtual screening protocol. Journal of Molecular Graphics and Modelling 92, 44-54, 2019. https://doi.org/10.1080/14756366.2019.1644329* Corresponding author
    • Atatreh N, Youssef AM, Ghattas MA, Al Sorkhy M, Alrawashdeh S, Al-Harbi KB, El-Ashmawy IM, Almundarij TI, Abdelghani AA, Abd-El-Aziz AS. Anti-inflammatory drug approach: Synthesis and biological evaluation of novel pyrazolo [3, 4-d] pyrimidine compounds. Biorganic Chemistry. 2019; 86: 393-400. https://doi.org/10.1016/j.bioorg.2019.02.014
    • Atatreh N, Ghattas MA, Bardaweel SK, Al Rawashdah S, Al Sorkhy M. Identification of new inhibitors of Mdm2–p53 interaction via pharmacophore and structure-based virtual screening. Drug Design, Development and Therapy 2018, 12, 1-12. 
    • Ghattas MA, Bryce RA, AlRawashdah S, Atatreh N, Zalloum WA. Comparative Molecular Dynamics Simulation of Aggregating and Non-Aggregating Inhibitor Solutions: Understanding the Molecular Basis of Promiscuity. ChemMedChem 2018, 13 (6), 500-506. https://doi.org/10.1002/cmdc.201700654
    • AlNeyadi SS, Salem AA, Ghattas MA, Atatreh N, Abdou IM. Antibacterial activity and mechanism of action of the benzazole acrylonitrile-based compounds: In vitro, spectroscopic, and docking studies. European Journal of Medicinal Chemistry 2017, 136, 270–282. DOI: https://doi.org/10.1016/j.ejmech.2017.05.010
    • Ghattas MA, Eissa NA, Bardaweel SK, Abu Mellal A, Atatreh N. Computer-aided discovery of antimicrobial agents as potential enoyl acyl carrier protein reductase inhibitors, Tropical Journal of Pharmaceutical Research 2017, 16 (2), 397-405. http://dx.doi.org/10.4314/tjpr.v16i2.19
    • Hertecant J, Komara M, Nagi A, Al-Zaabi O, Fathallah W, Cui H, Yang Y, Eng CM, Al Sorkhy M, Ghattas MA, Al-Gazali L, Ali BR. A de novo mutation in the X-linked PAK3 gene is the underlying cause of intellectual disability and macrocephaly in monozygotic twins. European Journal of Medical Genetics 2017, 60 (4), 212-216. http://doi.org/10.1016/j.ejmg.2017.01.004
    • Basim A, Muhi-Eldeen ZA, Al-Kaissi E, Sauifan G, Ghattas MA, Arafat T, Al-Adham I. Design, synthesis and biological screening of aminoacetylenic tetrahydrophthalimide analogues as novel COX inhibitors. International Journal of Pharmacy and Pharmaceutical Sciences 2017, 9(2):160. DOI: 10.22159/ijpps.2017v9i2.15511
    • Ghattas MA, Raslan N, Sadeq A, Al Sorkhy M, Atatreh N. Druggability analysis and classification of protein tyrosine phosphatase active sites. Drug Design, Development and Therapy 2016, 10:3197-3209. DOI 10.2147/DDDT.S111443
    • Ghattas MA, Mansour RA, Atatreh N, Bryce RA. Analysis of enoyl acyl carrier protein reductase structure and interactions yield an efficient virtual screening approach and suggest a potential allosteric site. Chemical Biology and Drug Design. 87(1): 131–142, 2016. DOI: 10.1111/cbdd.12635
    • Al-Jomaily M, Arafat T, Al-Kaissi E, Ghattas MA, Muhi-Eldeen Z. Synthesis of amino acetylenic benzophenone derivatives as H3-antagonists. International Journal of Pharmacy and Pharmaceutical Sciences. 7(6):174-179, 2015.
    • Qinna NA, Shubbar MH, Matalka KZ, Al‐Jbour N, Ghattas MA, Badwan AA. Glucosamine Enhances Paracetamol Bioavailability by Reducing Its Metabolism. Journal of Pharmaceutical Sciences. 2015:104:257–265. DOI: 10.1002/jps.24269
    • Sadek B, Khanian S, Ashoor A, Prytkova T, Ghattas MA, Atatreh N, Nurulain SM, Yang KS, Howarth FC, Oz M. Effects of antihistamines on the function of Human α7-nicotinic acetylcholine receptors. European Journal of Pharmacology. 2015; 746: 308–316. DOI:10.1016/j.ejphar.2014.10.046
    • Al-Rahmani R, Al-kaissi E, Arafat T, Ghattas M, Muhi-eldeen Z. Synthesis of 2-[{4-(t-amino-1-yl)but-2-yn-1-yl }oxy]-1,3-benzothiazole derivatives as H3-antagonists. IOSR Journal of Pharmacy. 2014; 4(9):40-49. DOI: 10.9790/3013-0409040049
    • Ghattas MA, Atatreh N, Bichenkova EV, Bryce RA. Protein tyrosine phosphatases: Ligand interaction analysis and optimisation of virtual screening. Journal of Molecular Graphics and Modelling. 2014; 52. 114-123. DOI:10.1016/j.jmgm.2014.06.011
    •  Qinna NA, Muhi-Eldeen ZA, Ghattas M, Alhussainy TM, Al-Qaisi J, Matalka KZ. Non-selective inhibition of cyclooxygenase enzymes by aminoacetylenic isoindoline 1,3-diones. Inflamm Allergy Drug Targets. 2012; 11:369-74. DOI: 10.2174/187152812803250999
    • Morrow CJ, Ghattas M, Smith C, Bönisch H, Bryce RA, Hickinson DM, Green, TP, Dive C. Src Family Kinase Inhibitor Saracatinib (AZD0530) Impairs Oxaliplatin Uptake in Colorectal Cancer Cells and Blocks Organic Cation Transporters. Cancer Research. 2010; 70: 5931-5941. DOI: 10.1158/0008-5472.CAN-10-0694

المواد التدريسية

  • Medicinal Chemistry
  • Biochemistry

العضويات

  • Member of the Molecular Graphics and Modelling Society (MGMS), UK.
  • Member of American Association of Cancer Research, USA.
  • Member of the Jordanian Pharmaceutical Association, Jordan.