أ. د. محمد أحمد غطاس

عميد كلية الصيدلة

أستاذ

مقر أبوظبي

+971 2 6133275

Pharmacy@aau.ac.ae

التعليم

Ph.D. Medicinal Chemistry, School of Pharmacy and Pharmaceutical Sciences, The University of Manchester, Manchester, UK

B.Pharm. Faculty of Pharmacy, Phildephia University – Amman, Jordan

الاهتمامات البحثية

My research interest lies in the field of computer-aided drug design where I focus in three main areas:

(1) Designing and discovery of new inhibitors for different drug targets using structure-based and ligand-based approaches;

(2) Assessing protein structures in terms of pocket protein-ligand interactions and druggability:

(3) Investigating the aggregation molecular behavior of small organic molecules using molecular dynamics simulations.

منشورات مختارة

  • A Nesabi, J Kalayan, S Al-Rawashdeh, MA Ghattas, RA Bryce. Molecular dynamics simulations as a guide for modulating small molecule aggregation. Journal of Computer-Aided Molecular Design, 2024, 38 (1), 11
  • RE Mahgoub, FE Mohamed, BR Ali, J Ferreira, WM Rabeh, N Atatreh, MA Ghattas*Discovery of pyrimidoindol and benzylpyrrolyl inhibitors targeting SARS-CoV-2 main protease (Mpro) through pharmacophore modelling, covalent docking, and biological evaluation. Journal of Molecular Graphics and Modelling, 2024, 127, 108672
  • Hasan S, Kayed K, Ghemrawi R, ... Atatreh N, Ghattas MA*. Molecular Modelling Study and Antibacterial Evaluation of Diphenylmethane Derivatives as Potential FabI Inhibitors. Molecules, 2023, 28(7), 3000
  • Kharaba Z, AlAhmad MM, Ahmed Elnour A, ... Abumweis S, Ghattas, MA. Are we ready yet for digital transformation? Virtual versus on-campus OSCE as assessment tools in pharmacy education. A randomized controlled head-to-head comparative assessment. Saudi Pharmaceutical Journal, 2023, 31(3), 359–369.
  • Salem AA, El Haty, IA, Ghattas MA. GW-2974 and SCH-442416 modulators of tyrosine kinase and adenosine receptors can also stabilize human telomeric G-quadruplex DNA. PLoS ONE, 2022, 17(12 December), e0277963
  • Mahgoub RE, Mohamed FE, Alzyoud L, ...Atatreh N, Ghattas MA*. The Discovery of Small Allosteric and Active Site Inhibitors of the SARS-CoV-2 Main Protease via Structure-Based Virtual Screening and Biological Evaluation Molecules, 2022, 27(19), 6710.
  • Alzyoud L, Ghattas MA*Atatreh N. Allosteric Binding Sites of the SARS-CoV-2 Main Protease: Potential Targets for Broad-Spectrum Anti-Coronavirus Agents. Drug Design, Development and Therapy. 2022, 16, 2463–2478.
  • Alzyoud L, Bryce RA, Al Sorkhy M, Atatreh N, Ghattas MA*. Structure-based assessment and druggability classification of protein-protein interaction sites. Scientific Reports2022, 12(1), 7975
  • Ghemrawi R, Khair M, Hasan S, Aldulaymi R, AlNeyadi SS, Atatreh N, Ghattas MA*. The Discovery of Potent SHP2 Inhibitors with Anti-Proliferative Activity in Breast Cancer Cell Lines. International journal of molecular sciences 23 (8), 4468 https://doi.org/10.3390/ijms23084468
  • Al Neyadi SS, Adem A, Amer N, Ghattas MA, Atatreh N, Salem AA, Abdou IM. Activation of the GLP-1 receptor by chloropyrimidine derivatives. Results in Chemistry. 3, 2021, 100222. https://doi.org/10.1016/j.rechem.2021.100222
  • * Corresponding Author.

المواد التدريسية

  • Drug Discvoery & Design (MSc.)
  • Medicinal Chemistry I (BSc.)
  • Medicinal Chemistry II (BSc.)

 

أهداف التنمية المستدامة المرتبطة بالخبرات

في عام 2015 اتفقت الدول الأعضاء في الأمم المتحدة على 17 هدفًا للتنمية المستدامة لإنهاء الفقر، وحماية الكوكب، وضمان الرفاه للجميع.

تساهم خبرة هذه الشخصية في أهداف التنمية المستدامة التالية:

  

العضويات

  • Member of Royal Society of Chemistry (MRSC), UK.
  • Member of American Chemical Society, USA.
  • Member of the Jordanian Pharmaceutical Association, Jordan.