Mohammad Ahmad Ghattas, Ph.D

Deputy Dean, College of Pharmacy

Abu Dhabi Campus

pharmacy_ad@aau.ac.ae

Education

Ph.D. Medicinal Chemistry, School of Pharmacy and Pharmaceutical Sciences, The University of Manchester, Manchester, UK

B.Pharm. Faculty of Pharmacy, Phildephia University – Amman, Jordan

Research Interests

My research interest lies in the field of computer-aided drug design where I focus in three main areas: (1) Designing and discovery of new inhibitors for different drug targets using structure-based and ligand-based approaches; (2) Assessing protein structures in terms of pocket protein-ligand interactions and druggability: (3) Investigating the aggregation molecular behavior of small organic molecules using molecular dynamics simulations.

Selected Publications

  • Atatreh N, Ghattas MA, Bardaweel SK, Al Rawashdah S, Al Sorkhy M. Identification of new inhibitors of Mdm2–p53 interaction via pharmacophore and structure-based virtual screening. Drug Design, Development and Therapy 2018, 12, 1-12. 
  • Ghattas MA, Bryce RA, AlRawashdah S, Atatreh N, Zalloum WA. Comparative Molecular Dynamics Simulation of Aggregating and Non-Aggregating Inhibitor Solutions: Understanding the Molecular Basis of Promiscuity. ChemMedChem 2018, 13 (6), 500-506. https://doi.org/10.1002/cmdc.201700654
  • AlNeyadi SS, Salem AA, Ghattas MA, Atatreh N, Abdou IM. Antibacterial activity and mechanism of action of the benzazole acrylonitrile-based compounds: In vitro, spectroscopic, and docking studies. European Journal of Medicinal Chemistry 2017, 136, 270–282. DOI: https://doi.org/10.1016/j.ejmech.2017.05.010
  • Ghattas MA, Eissa NA, Bardaweel SK, Abu Mellal A, Atatreh N. Computer-aided discovery of antimicrobial agents as potential enoyl acyl carrier protein reductase inhibitors, Tropical Journal of Pharmaceutical Research 2017, 16 (2), 397-405. http://dx.doi.org/10.4314/tjpr.v16i2.19
  • Hertecant J, Komara M, Nagi A, Al-Zaabi O, Fathallah W, Cui H, Yang Y, Eng CM, Al Sorkhy M, Ghattas MA, Al-Gazali L, Ali BR. A de novo mutation in the X-linked PAK3 gene is the underlying cause of intellectual disability and macrocephaly in monozygotic twins. European Journal of Medical Genetics 2017, 60 (4), 212-216. http://doi.org/10.1016/j.ejmg.2017.01.004
  • Basim A, Muhi-Eldeen ZA, Al-Kaissi E, Sauifan G, Ghattas MA, Arafat T, Al-Adham I. Design, synthesis and biological screening of aminoacetylenic tetrahydrophthalimide analogues as novel COX inhibitors. International Journal of Pharmacy and Pharmaceutical Sciences 2017, 9(2):160. DOI: 10.22159/ijpps.2017v9i2.15511
  • Ghattas MA, Raslan N, Sadeq A, Al Sorkhy M, Atatreh N. Druggability analysis and classification of protein tyrosine phosphatase active sites. Drug Design, Development and Therapy 2016, 10:3197-3209. DOI 10.2147/DDDT.S111443
  • Ghattas MA, Mansour RA, Atatreh N, Bryce RA. Analysis of enoyl acyl carrier protein reductase structure and interactions yield an efficient virtual screening approach and suggest a potential allosteric site. Chemical Biology and Drug Design. 87(1): 131–142, 2016. DOI: 10.1111/cbdd.12635
  • Al-Jomaily M, Arafat T, Al-Kaissi E, Ghattas MA, Muhi-Eldeen Z. Synthesis of amino acetylenic benzophenone derivatives as H3-antagonists. International Journal of Pharmacy and Pharmaceutical Sciences. 7(6):174-179, 2015.
  • Qinna NA, Shubbar MH, Matalka KZ, Al‐Jbour N, Ghattas MA, Badwan AA. Glucosamine Enhances Paracetamol Bioavailability by Reducing Its Metabolism. Journal of Pharmaceutical Sciences. 2015:104:257–265. DOI: 10.1002/jps.24269
  • Sadek B, Khanian S, Ashoor A, Prytkova T, Ghattas MA, Atatreh N, Nurulain SM, Yang KS, Howarth FC, Oz M. Effects of antihistamines on the function of Human α7-nicotinic acetylcholine receptors. European Journal of Pharmacology. 2015; 746: 308–316. DOI:10.1016/j.ejphar.2014.10.046
  • Al-Rahmani R, Al-kaissi E, Arafat T, Ghattas M, Muhi-eldeen Z. Synthesis of 2-[{4-(t-amino-1-yl)but-2-yn-1-yl }oxy]-1,3-benzothiazole derivatives as H3-antagonists. IOSR Journal of Pharmacy. 2014; 4(9):40-49. DOI: 10.9790/3013-0409040049
  • Ghattas MA, Atatreh N, Bichenkova EV, Bryce RA. Protein tyrosine phosphatases: Ligand interaction analysis and optimisation of virtual screening. Journal of Molecular Graphics and Modelling. 2014; 52. 114-123. DOI:10.1016/j.jmgm.2014.06.011
  •  Qinna NA, Muhi-Eldeen ZA, Ghattas M, Alhussainy TM, Al-Qaisi J, Matalka KZ. Non-selective inhibition of cyclooxygenase enzymes by aminoacetylenic isoindoline 1,3-diones. Inflamm Allergy Drug Targets. 2012; 11:369-74. DOI: 10.2174/187152812803250999
  • Morrow CJ, Ghattas M, Smith C, Bönisch H, Bryce RA, Hickinson DM, Green, TP, Dive C. Src Family Kinase Inhibitor Saracatinib (AZD0530) Impairs Oxaliplatin Uptake in Colorectal Cancer Cells and Blocks Organic Cation Transporters. Cancer Research. 2010; 70: 5931-5941. DOI: 10.1158/0008-5472.CAN-10-0694

Teaching Courses

  • Medicinal Chemistry
  • Biochemistry

Memberships

  • Member of the Molecular Graphics and Modelling Society (MGMS), UK.
  • Member of American Association of Cancer Research, USA.
  • Member of the Jordanian Pharmaceutical Association, Jordan.