مجموعة صياغة الأدوية وتحليلها وتوصيفها

 

للتواصل

د. خيري مصطفى
كلية الصيدلة، مبنى (P)
جامعة العين
ص. ب.: 64141، العين، دولة الإمارات العربية المتحدة
البريد الإلكترونيpharmacy@aau.ac.ae
هاتف: +971 3 7024866
فاكس: +971 3 7024777

 

نطاقات البحث

  • توصيل العقاقير المستهدفة
  • التركيبات الدوائية واختبارها داخل الجسم وفي المختبر
  • التركيبات الفيزيائية والكيميائية للأدوية
  • اختبار الثبات الدوائي
  • تطوير الطرق التحليلية للأدوية

 

اهتمامات البحث

في صياغة الأدوية وتحليلها وتوصيفها ، يركز بحثنا على:

  • تسليم الأدوية المستهدفة بما في ذلك خفض حجم الجسيمات، ودراسات تحميل ناقلات الأدوية
  • التركيبات الدوائية والاختبارات داخل الجسم وفي المختبر، التي تنطوي على إعداد أشكال الجرعات واختبار أداء المنتجات الدوائية في المختبر وفي الفئران
  • الخصائص الفيزيائية والكيميائية للأدوية عن طريق تحديد حجم الجسيمات ومساحة السطح ومعامل التوزيع النظري والتجريبي للأدوية
  • اختبار الثبات بما في ذلك الصيغ المختلفة ومنتجات الأدوية من حيث ثباتها في غرفة مسيطر عليها بيئياً
  • تطوير أساليب تحليلية من خلال استخدام تقنيات تحليلية بديلة و مبتكرة لتحليل الأدوية / المنتجات الموجودة والمواد المختبرة حديثا.

 

الأجهزة والإمكانيات البحثية المتوفرة

  • مختبر تكنولوجيا صيدلانية مجهز جيدًا
  • جهاز HPLC
  • جهاز مطياف (التحليل الطيفي) الامتصاص FTIR
  • جهاز مطياف (التحليل الطيفي)  الامتصاص الذري AAS

 

المنشورات

  1. Al Hanbali O, Khan H, Sarfraz MMosab Arafat. Transdermal patches: Design and current approaches to painless drug delivery. Acta Pharm 2019; 69 (1):1 - 19."Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society"
  2. Ftikhar S, Saqib A, Sarwar MR, Sarfraz M, Mosab Arafat, Shoaib QU. Capacity and willingness to use information technology for managing chronic diseases among patients: A cross-sectional study.  PLoS ONE 2019;14(1): e0209654 “USA
  3. Khalid N, Sarfraz MMosab Arafat, Akhtar M, Löebenberg R, Rahman N. Nano-sized Droplets of Self-emulsifying System for Enhancing Oral Bioavailability of Chemotherapeutic Agent VP-16 in Rats: A Nano Lipid Carrier for BCS Class IV Drugs. J Pharm Pharm Sci 2018; 21 (1):  398 - 408.   "Canadian Society for Pharmaceutical Sciences"
  4. Othman A Al Hanbali, Rania Hamed, Mosab Arafat, Youssef Bakkour, Hisham Al-Matubsi, Randa Mansour, Yazan Al-Bataineh, Mohammad Aldhoun, Muhammad Sarfraz, Abdel Khaleq Yousef Dardas. Formulation and evaluation of diclofenac controlled release matrix tablets made of HPMC and Poloxamer 188 polymer: An assessment on mechanism of drug releasePak J Pharm Sci 2018; 31: 1 (Suppl), p 345-351.
  5. Maira Faizullah, Nisar-Ur-Rahman, Muhammad Ihtesham Umar, Mudassir AnwarMuhammad Sarfraz. A cross-sectional study on knowledge, attitude and practices of medical doctors towards antibiotic prescribing patterns and resistance in Khyber Pakhtun Khawah. Journal of Applied Pharmaceutical Science; December 2017, Vol. 7 (12), pp. 038-046,
  6. Kamal T, Sarfraz M, Mosab ArafatMikov M, Rahman N. Cross-linked guar gum and sodium borate based microspheres as colon-targeted anticancer drug delivery systems for 5-fluorouracil. Pak J Pharm Sci 2017; 30: 6 (Suppl), 2329-2336
  7. Mosab Arafat, Muhammad Sarfraz, Kirchhoefer C, Mikov M., Löbenberg R. Dual Effect of Bile Salts in Nanocarriers: Counteracting Gastrointestinal Lysis and Enhancing The Oral Bioavailability of BCS Class III Drug. The Americana Association of Pharmaceutical Scientists Journal. AAPS Annual Meeting and Exposition. November 12-15, 2017. San Diego, California, USA.
  8. Mosab Arafat, Kirchhoefer C, Mikov M, Sarfraz M, Löbenberg M. Nanosized liposomes containing bile salt: a vesicular nanocarrier for enhancing oral bioavailability of BCS class III drug. J Pharm Pharm Sci 2017; 20: 305-318. DOI: 10.18433/J3CK88.
  9. Mosab Arafat, Zaha’a Ahmed, Osama Arafat. Comparison Between Generic Drugs and Brand Name Drugs From Bioequivalence and Thermoequivalence Prospective. International Journal of Pharmacy and Pharmaceutical Sciences. 2017; 9 (6): 1-4.
  10. Mosab Arafat, The effect of intestinal bile on the stability of lipid-based vesicular system used as oral drug carriers. Glob Drugs Therap 2016 (2)1:1-2: DOI: 10.15761/GDT.1000109
  11. Mosab ArafatCathrin Kirchhoefer, Momir Mikov. Mixed Micelles Loaded with Bile Salt: An Approach to Enhance Intestinal Transport of the BCS Class III Drug Cefotaxime in Rats. European Journal of Drug Metabolism and Pharmacokinetics. 2016, 42:.1-11. DOI: 10.1007/s13318-016-0375-9
  12. Mosab ArafatZaha’a Ahmed, Momir Mikov. Determination of Nifedipine in Rat Plasma Using HPLC-UV Detector: A Simple Method for Pharmacokinetics and Oral Bioavailability Studies. International Journal of Pharmacy and Pharmaceutical Sciences. 2016; 8 (8): 98-102.
  13. Mosab Arafat. Approaches to Achieve An Oral Controlled Release Drug Delivery System Using Polymers: A Recent Review. International Journal of Pharmacy and Pharmaceutical Sciences2015; 7 (7): 16-21.
  14. Moawia M. Al-Tabakha. Future prospect of insulin inhalation for diabetic patients: The case of Afrezza versus Exubera. J Control Release. 2015; 215 (10): 25-38. DOI: 10.1016/j.jconrel.2015.07.025.
  15. Hamad IM, Arida AI, Al-Tabakha MM. Effect of the lubricant Magnesium Stearate on Changes of Specific Surface Area of Directly Compressible Powders Under Compression. Jordan Journal of Pharmaceutical Sciences. 8(1): 21-33, 2015.
  16. Al-Tabakha MM, Arida AI, Fahelelbom KMS, Sadek B, Saeed DA, Abu Jarad RA, Jawadi J. Influence of capsule shell composition on the performance indicators of hypromellose capsule in comparison to hard gelatin capsules. Drug Development and Industrial Pharmacy. 2015; 41(10): 1726–1737. DOI: 10.3109/03639045.2014.1002409.
  17. Mosab Arafat , Svetlana Golocorbin Kon, Momir Mikov (2015). The Measurement of Cefotaxime Sodium in Rat Plasma After Oral Administration: A Sensitive HPLC-UV Method. International Journal of Pharmacy and Pharmaceutical Sciences. 2015; 7 (4) 343-346.
  18. Al-Tabakha MM, Arida AI, Fahelelbom KMS, Sadek B, Abu Jarad RA. Performances of New Generation of Delayed Release Capsules. Journal of Young Pharmacists. 2015; 7(1): 36-44. DOI:10.5530/jyp.2015.1.7
  19. Mosab Arafat  (2014). Simple HPLC Validated Method for Determination of Diltiazem Hydrochloride in Human. International Journal of Pharmacy and Pharmaceutical Sciences. 2014; 6 (9): 213-216.
  20. Mosab Arafat, Aisha Salam, Osama Arafat. The Association of Type 2 Diabetes with Obesity and Other factors: In Multinational Community. International Journal of Pharmacy and Pharmaceutical Sciences. 2014; 6 (9) 257-260.
  21. Al-Tabakha MM. HPMC Capsules: Current Status and Future Prospects. Journal of Pharmacy and Pharmaceutical Sciences. 13(3): 428-442, 2010.DOI: 10.4103/0250-474X.42968
  22. Muhammad Rehan, Anum Saqib, Tayyab Riaz, Haleema Aziz, Mosab Arafat, Hamna Nouman. Attitude, perception, willingness, motivation and barriers to practice-based research: A cross-sectional survey of hospital pharmacists in Lahore, Punjab, Pakistan.  PloS one 2018;13 (9), e0203568

 

المؤتمرات

  1. Mosab Arafat, C. Kirchhoefer, Muhammad Sarfraz, Raimar Löbenberg. Study the Effect of Physiological Fluid on Vesicles Membrane Stability of Liposomes containing Bile Salts using Calcein as a Marker for Vesicles Leakage. The Americana Association of Pharmaceutical Scientists Journal. AAPS Annual Meeting and Exposition. November 4-7, 2018Washington DC, USA.
  2. Mosab Arafat, Cathrin Kirchhoefer, Momir Mikov, Muhammad Sarfraz, Raimar Löebenberg. The enhancement of the poor oral bioavailability of cefotaxime sodium using nano-mixed micelles formulation. Canadian Society for Pharmaceutical Sciences. 2018 CSPS Annual Symposium. May 22 – 25, 2018Toronto, Canada.
  3. Muhammad Sarfraz, Nayab Khalid, Mosab Arafat, Muhammad Akhtar, Nisar-Ur- Rahman, Raimar Löebenberg. Nano-sized Droplets of Self-emulsifying System for Enhancing Oral Bioavailability of Etoposide in Rats.Canadian Society for Pharmaceutical Sciences. 2018 CSPS Annual Symposium. May 22 – 25, 2018Toronto, Canada.
  4. Mosab Arafat Muhammad Sarfraz, Kirchhoefer C, Mikov M., Löbenberg R. Dual Effect of Bile Salts in Nanocarriers: Counteracting Gastrointestinal Lysis and Enhancing The Oral Bioavailability of BCS Class III Drug. The Americana Association of Pharmaceutical Scientists Journal. AAPS Annual Meeting and Exposition. November 12-15, 2017. San Diego, California, USA.
  5. Mosab Arafat. The application of nanotechnology on drug delivery systems. Nanotechnology and Materials ScienceWorld Congress and Expo, 13th – 15th April 2015, Dubai, United Arab Emirates.
  6. Moawia Al-Tabakha, Khairi Fahelelbom, Dima Said and Rami Abu Jarad. Initial Disintegration of “Vegetable” Capsules and Hard Gelatin Capsules: In Vitro Comparison Study. 12-14 of March, 2012 (Dubai International Pharmaceuticals & Technologies Conference & Exhibition).
  7. Mosab Arafat  The oral bioavailability of cefotaxime in nano-vesicles formulation after introduced to rats. DUPHAT Conference, 10th – 12th March 2013, Dubai, United Arab Emirates.

 

تنزيل