Drug Formulations, Analysis and Characterization Group


Contact us

Dr. Khairi Salem
College of Pharmacy, Building P
Al Ain University of Science and Technology
P.O.Box: 64141 Al Ain, UAE
Email: pharmacy@aau.ac.ae
Phone: +971 3 7024866
Fax: +971 3 7024777


Research areas

  • Targeted drug delivery
  • Drug formulations and in vivo and in vitro testing
  • Physico-chemical characterization of drug
  • Stability testing
  • Development of analytical methods


Research interest

Our research focus on:

  • Targeted drug delivery including particle size reduction and drug-carrier loading studies.
  • Drug formulations and in vivo and in vitro testing, which involve preparation of dosage forms and testing drug products performance in vitro and in mice.
  • Physico-chemical characterization of drugs via determining particle size, surface area and theoretical and experimental partition coefficient of drugs.
  • Stability testing including different formulation and drug products are studied in terms of their stability in environmentally controlled chamber
  • Development of analytical methods via using alternative or innovative analytical techniques for analyzing existing drugs/products and newly synthesized ones.


Research facilities

  • Well-equipped pharmaceutical technology lab.
  • HPLC
  • FTIR Absorption Spectroscopy
  • Atomic Absorption Spectroscopy



  1. Othman A Al Hanbali, Rania Hamed, Mosab Arafat, Youssef Bakkour, Hisham Al-Matubsi, Randa Mansour, Yazan Al-Bataineh, Mohammad Aldhoun, Muhammad Sarfraz, Abdel Khaleq Yousef Dardas. Formulation and evaluation of diclofenac controlled release matrix tablets made of HPMC and Poloxamer 188 polymer: An assessment on mechanism of drug releasePak J Pharm Sci 2018; 31: 1 (Suppl), p 345-351.
  2. Maira Faizullah, Nisar-Ur-Rahman, Muhammad Ihtesham Umar, Mudassir AnwarMuhammad Sarfraz. A cross-sectional study on knowledge, attitude and practices of medical doctors towards antibiotic prescribing patterns and resistance in Khyber Pakhtun Khawah. Journal of Applied Pharmaceutical Science; December 2017, Vol. 7 (12), pp. 038-046,
  3. Kamal T, Sarfraz M, Mosab ArafatMikov M, Rahman N. Cross-linked guar gum and sodium borate based microspheres as colon-targeted anticancer drug delivery systems for 5-fluorouracil. Pak J Pharm Sci 2017; 30: 6 (Suppl), 2329-2336
  4. Mosab Arafat, Muhammad Sarfraz, Kirchhoefer C, Mikov M., Löbenberg R. Dual Effect of Bile Salts in Nanocarriers: Counteracting Gastrointestinal Lysis and Enhancing The Oral Bioavailability of BCS Class III Drug. The Americana Association of Pharmaceutical Scientists Journal. AAPS Annual Meeting and Exposition. November 12-15, 2017. San Diego, California, USA.
  5. Mosab Arafat, Kirchhoefer C, Mikov M, Sarfraz M, Löbenberg M. Nanosized liposomes containing bile salt: a vesicular nanocarrier for enhancing oral bioavailability of BCS class III drug. J Pharm Pharm Sci 2017; 20: 305-318. DOI: 10.18433/J3CK88.
  6. Mosab Arafat, Zaha’a Ahmed, Osama Arafat. Comparison Between Generic Drugs and Brand Name Drugs From Bioequivalence and Thermoequivalence Prospective. International Journal of Pharmacy and Pharmaceutical Sciences. 2017; 9 (6): 1-4.
  7. Mosab Arafat, The effect of intestinal bile on the stability of lipid-based vesicular system used as oral drug carriers. Glob Drugs Therap 2016 (2)1:1-2: DOI: 10.15761/GDT.1000109
  8. Mosab ArafatCathrin Kirchhoefer, Momir Mikov. Mixed Micelles Loaded with Bile Salt: An Approach to Enhance Intestinal Transport of the BCS Class III Drug Cefotaxime in Rats. European Journal of Drug Metabolism and Pharmacokinetics. 2016, 42:.1-11. DOI: 10.1007/s13318-016-0375-9
  9. Mosab ArafatZaha’a Ahmed, Momir Mikov. Determination of Nifedipine in Rat Plasma Using HPLC-UV Detector: A Simple Method for Pharmacokinetics and Oral Bioavailability Studies. International Journal of Pharmacy and Pharmaceutical Sciences. 2016; 8 (8): 98-102.
  10. Mosab Arafat. Approaches to Achieve An Oral Controlled Release Drug Delivery System Using Polymers: A Recent Review. International Journal of Pharmacy and Pharmaceutical Sciences2015; 7 (7): 16-21.
  11. Moawia M. Al-Tabakha. Future prospect of insulin inhalation for diabetic patients: The case of Afrezza versus Exubera. J Control Release. 2015; 215 (10): 25-38. DOI: 10.1016/j.jconrel.2015.07.025.
  12. Hamad IM, Arida AI, Al-Tabakha MM. Effect of the lubricant Magnesium Stearate on Changes of Specific Surface Area of Directly Compressible Powders Under Compression. Jordan Journal of Pharmaceutical Sciences. 8(1): 21-33, 2015.
  13. Al-Tabakha MM, Arida AI, Fahelelbom KMS, Sadek B, Saeed DA, Abu Jarad RA, Jawadi J. Influence of capsule shell composition on the performance indicators of hypromellose capsule in comparison to hard gelatin capsules. Drug Development and Industrial Pharmacy. 2015; 41(10): 1726–1737. DOI: 10.3109/03639045.2014.1002409.
  14. Mosab Arafat , Svetlana Golocorbin Kon, Momir Mikov (2015). The Measurement of Cefotaxime Sodium in Rat Plasma After Oral Administration: A Sensitive HPLC-UV Method. International Journal of Pharmacy and Pharmaceutical Sciences. 2015; 7 (4) 343-346.
  15. Al-Tabakha MM, Arida AI, Fahelelbom KMS, Sadek B, Abu Jarad RA. Performances of New Generation of Delayed Release Capsules. Journal of Young Pharmacists. 2015; 7(1): 36-44. DOI:10.5530/jyp.2015.1.7
  16. Mosab Arafat  (2014). Simple HPLC Validated Method for Determination of Diltiazem Hydrochloride in Human. International Journal of Pharmacy and Pharmaceutical Sciences. 2014; 6 (9): 213-216.
  17. Mosab Arafat, Aisha Salam, Osama Arafat. The Association of Type 2 Diabetes with Obesity and Other factors: In Multinational Community. International Journal of Pharmacy and Pharmaceutical Sciences. 2014; 6 (9) 257-260.
  18. Al-Tabakha MM. HPMC Capsules: Current Status and Future Prospects. Journal of Pharmacy and Pharmaceutical Sciences. 13(3): 428-442, 2010.DOI: 10.4103/0250-474X.42968
  19. Muhammad Rehan, Anum Saqib, Tayyab Riaz, Haleema Aziz, Mosab Arafat, Hamna Nouman. Attitude, perception, willingness, motivation and barriers to practice-based research: A cross-sectional survey of hospital pharmacists in Lahore, Punjab, Pakistan.  PloS one 2018;13 (9), e0203568



  1. Mosab Arafat, C. Kirchhoefer, Muhammad Sarfraz, Raimar Löbenberg. Study the Effect of Physiological Fluid on Vesicles Membrane Stability of Liposomes containing Bile Salts using Calcein as a Marker for Vesicles Leakage. The Americana Association of Pharmaceutical Scientists Journal. AAPS Annual Meeting and Exposition. November 4-7, 2018Washington DC, USA.
  2. Mosab Arafat, Cathrin Kirchhoefer, Momir Mikov, Muhammad Sarfraz, Raimar Löebenberg. The enhancement of the poor oral bioavailability of cefotaxime sodium using nano-mixed micelles formulation. Canadian Society for Pharmaceutical Sciences. 2018 CSPS Annual Symposium. May 22 – 25, 2018Toronto, Canada.
  3. Muhammad Sarfraz, Nayab Khalid, Mosab Arafat, Muhammad Akhtar, Nisar-Ur- Rahman, Raimar Löebenberg. Nano-sized Droplets of Self-emulsifying System for Enhancing Oral Bioavailability of Etoposide in Rats.Canadian Society for Pharmaceutical Sciences. 2018 CSPS Annual Symposium. May 22 – 25, 2018Toronto, Canada.
  4. Mosab Arafat Muhammad Sarfraz, Kirchhoefer C, Mikov M., Löbenberg R. Dual Effect of Bile Salts in Nanocarriers: Counteracting Gastrointestinal Lysis and Enhancing The Oral Bioavailability of BCS Class III Drug. The Americana Association of Pharmaceutical Scientists Journal. AAPS Annual Meeting and Exposition. November 12-15, 2017. San Diego, California, USA.
  5. Mosab Arafat. The application of nanotechnology on drug delivery systems. Nanotechnology and Materials ScienceWorld Congress and Expo, 13th – 15th April 2015, Dubai, United Arab Emirates.
  6. Moawia Al-Tabakha, Khairi Fahelelbom, Dima Said and Rami Abu Jarad. Initial Disintegration of “Vegetable” Capsules and Hard Gelatin Capsules: In Vitro Comparison Study. 12-14 of March, 2012 (Dubai International Pharmaceuticals & Technologies Conference & Exhibition).
  7. Mosab Arafat  The oral bioavailability of cefotaxime in nano-vesicles formulation after introduced to rats. DUPHAT Conference, 10th – 12th March 2013, Dubai, United Arab Emirates.