Education

Ph.D. Medicinal Chemistry, School of Pharmacy and pharmaceutical sciences, Cardiff University, Cardiff, UK

Master's degree (M.Sc.) in pharmaceutical sciences, Zagazig University, Egypt

Bachelor (B.Sc.) in Pharmaceutical sciences, Zagazig University, Egypt

Research Interests

My research interest lies in the field of Medicinal Chemistry. Some of the current work and future ideas that are being executed can be summarised as follows:

1. Multi targeting of biological targets in the same or different biochemical pathways involved in cancer can offer alternative therapeutic approaches to overcome drug resistance (e.g., Dual targeting of aromatase and sulfatase enzymes in breast cancer).
2. Antimicrobial resistance is driving the urge of finding novel microbial targets that could be crucial for the bacterial survival and welfare (e.g., Aminoacyl t-RNA synthetase inhibitors).
3. Repurposing of currently available drugs in the market through screening to find promising drugs that can act as anti-biofilm or anti-quorum sensing to help in the fight against multi-drug resistant bacteria.

Selected Publications

• Eissa, A.G., Gozzi, F., Aloqab, O., Parrish, C.E., Mohamed, N., Shiali, I., Al-Baldawi, H., Foster, P.A. and Simons, C., 2025. Development of benzofuran-derived sulfamates as dual aromatase-steroid sulfatase inhibitors (DASIs): design, synthesis and biological evaluation. RSC Medicinal Chemistry, 16(4), pp.1606-1618.

Professional Experience

• Ph.D. Thesis: “4th Generation aromatase inhibitors for the treatment of breast cancer: design, synthesis, biochemical and molecular biology studies” (2021).
• M.Sc. Thesis: “Exploring aminoacyl-tRNA synthetase inhibitors as novel anti-infective drugs” (2016).
• My research experience includes the design and synthesis of small molecules. During my PhD studies and afterwards, I have been involved in the drug discovery process starting from the design and computer-aided drug design (molecular docking, modelling and molecular dynamics and other computational processes), then the development of synthetic schemes for small molecules. I have extensive experience in the synthesis of small molecules and their modifications with complete analysis for the products (NMR, HPLC, and interpretation of MS). I have also been involved during my PhD study in cell culture work.

Teaching Courses

• Medicinal Chemistry (B.Sc.)
• Organic Chemistry (B.Sc.)
• Advanced pharmaceutical chemistry (M.Sc.)
• Chemsitry (B.Sc.)
• Artificial Intelligence in drug discovery (M.Sc.)

 

Expertise related to UN Sustainable Development Goals

 

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all.

This person’s work contributes towards the following SDG(s):

Memberships

Member of American Chemical Society (ACS), USA.