Ph.D. Biomedical Sciences, College of Medicine and Health Sciences, UAE University, UAE
MSc. University of London, UK
MBBS Baqai Medical University, Pakistan
Glutamate signalling pathway, diabetic neuropathy, pathogenesis of diabetic complications
- Hussain N, SA Said A, Baig M (2020), Levels of Vitamin D and Vitamin D pathway gene polymorphisms in adults: results based on rural agriculture workers in punjab province of Pakistan, Progress in Nutrition, Mattioli Health, Vol 22 No 2 (2020), DOI: 10.23751/pn.v22i2.8180, https://mattioli1885journals.com/index.php/progressinnutrition/article/view/8180
- Abu Mellal A, Hussain N, Said ASA, M A (2019), The Clinical Significance of Statins - Macrolides Interaction: Comprehensive Review of In vivo, Case-reports and Population Studies, Therapeutics and Clinical Risk Management, Dove press, 2019:15 Pages 921—936, DOI: 10.2147/TCRM.S214938
- Hussain N, SA Said A, Khan Z (2018), Safety Assessment of Neoadjuvant Pertuzumab Combined with Trastuzumab in Nonmetastatic HER2-Positive Breast Cancer in Postmenopausal Elderly Women of South Asia, International Journal of Breast Cancer, Volume 2018
- Said A, Hussain N, Al Haddad AHI, Javid F. Effects of Alogliptin on hypertensive chronic kidney disease with Type 2 diabetes mellitus. AMJ 2018;11(2):113–123
- Mahdy A, Hussain N, Al Khalidi D, SA Said A (2017), Knowledge, attitude, and practice analysis of corticosteroid use among patients: A study based in the United Arab Emirates (2017), Natl J Physiol Pharm Pharmacol. 2017; 7(6): 562-568
- Hussain N (2015), Haemoglobin A1C and iron deficiency anaemia: our understanding thorugh the decades. Romanian Journal of Diabetes and metabolism 2015; 3 (22): 289–296
- Hussain N (2015), Implications of using HbA1c as a diagnostic test for diabetes. Diabetology international journal (in press)
- Hussain N, Adrian TE (2017), Diabetic Neuropathy: Update on Pathophysiological Mechanism and the Possible Involvement of Glutamate Pathways. Current Diabetes Reviews 2017;13(5):488-497
- SA Said A, Hussain N (2017), Adverse Drug Reaction Reporting Practices Among United Arab Emirates Pharmacists and Prescribers, Hospital Pharmacy. Vol 52, Issue 5, pp. 361 – 366
- Hussain N, Parekh K, Mensah-Brown E, Howarth FC, Adrian TE (2015), Early gene expression changes in streptozotocin induced rat, UAEU Research, UAE University
- Hussain N (2015), The effect of risk factors on health-related quality of life in paediatric epileptic patients. Epilepsy Society 2015
- Hussain N (2015), The use of prophylactic antibiotics in haematopoeitic stem cell transplantation. Emirates Haemotology society 2015
- Hussain N (2015), Echocardiographic aortic root dilatation in hypertensive subjects observations from a meta-analysis. Interventional Radiology Society 2015
- Hussain N (2014), Skin temperature is predictive of diabetic foot ulceration – a systematic review. Wound Care Society 2014
- Hussain N (2014), Haemoglobin variants affect HbA1C. American Association of Clinical Endocrinologists Society 2014
- Hussain N, Ahmed SA (2018), Poster presentation “Impact of Cognitive Rehabilitation On Memory Outcome: Results of Epileptic Patients Undergoing Temporal Lobe Resection Surgery” in 6th UAE Epilepsy conference, October 26, UAE.
- Hussain N, Ahmed SA (2017), Poster presentation “Tolerability, safety profile and efficacy of nintedanib for patients with pulmonary fibrosis” in 3rd Abu Dhabi Pharmacy Conference, April 26 2018, Abu Dhabi, UAE.
- Hussain N, Ahmed SA (2017), Poster presentation “Presence of fever in the emergency room in severe sepsis patients predicts survival in ICU” at International growth and Development conference, March 2018, Dubai, UAE.
- Hussain N, Ahmed SA (2017), Poster presentation “Screening tests for the diagnosis of distal symmetrical polyneuropathy in type 2 diabetes mellitus: results from a cross sectional study in South Asian patients” at 8th Emirates Diabetes and Endocrine congress, March 2018, Dubai, UAE.
- Hussain N, Ahmed SA (2017), Poster presentation “Presence of fever in the emergency room in severe sepsis patients predicts survival in ICU” at 1st Emirates Family Medicine Conference, January 2018, Dubai, UAE.
- Hussain N (2017), Oral presentation “The role of glutamate signaling in diabetic neuropathy” at AAU Scientific Day, January 2018, Dubai, UAE.
- Hussain N, Poster presentation “Evaluating The Effect Of Allopurinol Use On Cardiovascular Outcomes In Adults With Diagnosed Hypertension”, at 8th Annual Emirates Cardiac Society Conference, October 2017, Dubai, UAE
- Hussain N, Ahmed SA (2017), Poster presentation “Screening tests for the diagnosis of distal symmetrical polyneuropathy in type 2 diabetes mellitus: results from a cross sectional study in South Asian patients” at Fifth Annual congress of American Association of Clinical Endocrinologists Gulf Chapter October 2017, Dubai, UAE
- Hussain N, Ahmed SA, Al Haddad Hussain A (2017), Poster presentation at 6th International Conference On Vitamin D Deficiency,March 2017, “Vitamin D levels and response to Hepatitis C therapy”
- Hussain N, Ahmed SA (2017), Poster presentation at PAIRS, March 2017, “Safety Assessment of Continuous Versus Discontinuous Warfarin Therapy in Cardiovascular Endovascular Procedures: Observations from a Meta-Analysis”
- Hussain N, Ahmed SA, Al Haddad Hussain A (2017), Poster presentation at MedEdDXB 2017, March 2017, “The role of technology enhanced simulation in the field of pediatric education”
- Hussain N, Ahmed SA, Al Haddad Hussain A (2017), Emirates hematology conference March 2017, “The potential chemopreventive role of statins against haematological malignancies: observations from a meta-analysis”
- Hussain N, Ahmed SA, Al Haddad Hussain A (2017), Emirates hematology conference March 2017, “Assessing brain MRI and neurological complications in adults undergoing hematopoietic cell transplantation for hematologic malignancies: comparison of a study involving the pre- and post-allogeneic cell transplant (HCT) stage.”
- Hussain N, Ahmed SA (2017), Poster presentation at 7th Endocrine and Diabetes conference, February 2017, “The effect of aerobic exercise or resistance exercise on glycaemic control in type 2 diabetes mellitus: results from an interventional trial” – 3rd best poster presentation award
- Hussain N (2016), Poster presentation at UAEU Symposium on biological sciences (genomics and bioinformatics), November 2016, “Analysis of Mendelian randomization studies of biomarkers and type 2 diabetes: observations from analysis”
- Hussain N, Ahmed SA (2016), Oral presentation at Assessment Leadership Institute, November 2016, “The influence of technology on assessment design: observations from focus study on university faculty members”
- Hussain N (2016), Oral presentation at 2nd UAE graduate student conference, April 2016, “Diabetic neuropathy and the glutamate pathways”
- Hussain N (2016), Poster presentation at 7th Abu Dhabi Wound care conference, April 21-22 2016“Wound closure in knee arthroplasty: observations from a meta analysis about the effect of knotted versus traditional sutures in knee arthoplasty outcomes”
- Hussain N (2016), Poster presentation at DUPHAT, March 2016 “The effect of ondansetron on the efficacy of postoperative tramadol: observation from a meta analysis of drug interaction”
- Hussain N (2016), Poster presentation at Multidisciplinary conference, Feb 2016, Al Ain University of Science and Technology, Al Ain, UAE “Associations between Using Noninsulin Blood Glucose Lowering Drugs and Heart Failure: Observations from A Meta-Analysis”
- Hussain N (2016), Poster presentation at 6th Pan Arab Genetics conference, 21-23 Jan 2016, Dubai, UAE “Associations of Genetic Variants In/near Body Mass Index-associated Genes with Type 2 Diabetes: Observations from A Meta-analysis”
- Hussain N (2015), Oral presentation at UAEU Research and Innovation conference, November 2015, Al Ain, UAE on “The role of glutamate signaling in diabetic neuropathy”
- Hussain N (2015), Poster presentation at American Association of Clinical Endocrinologists – Gulf Chapter Annual meeting, 3rd Clinical congress, November 2015 “Diabetes Associated Cognitive Decline: Observations and Conclusions From a Meta-analysis”
- Hussain N (2015), Poster accepted at First Pan Arab Thalassaemia&Haemoglobinopathies Conference, November 2015 “Comparison of exchange transfusion for perioperative complications in elective surgery on sickle cell anemia patients: observations from a meta analysis”
- Hussain N (2015), Oral presentation at UAE National Graduate Student Research conference, Abu Dhabi, March 2015 on “Early gene expression changes in STZ rat model for diabetic neuropathy”
- 1st prize winner in Health and Life sciences category in UAE National Graduate Student Research conference, Abu Dhabi March 2015 for above paper.
- Hussain N (2015), Poster presentation at Research day, May 2015, UAE University on “Early gene expression changes in STZ rat model for diabetic neuropathy”
- Hussain N (2015), Oral presentation at The Fourth Annual UAE Epilepsy Congress 2015, May 2015 on “The effect of risk factors on health-related quality of life in pediatric epileptic patients: observations from a meta-analysis”.
- Hussain N (2015), Oral presentation at 6th Abu Dhabi Wound Care conference, March 2015 on “Skin temperature is predictive of diabetic foot ulceration – a meta-analysis and systematic review”
- Hussain N (2015), Oral presentation at 5th Emirates Haemotology conference, March 2015 on “The use of prophylactic antibiotics in haematopoeitic stem cell transplantation”.
- Hussain N (2015), Oral presentation accepted at Abu Dhabi Neuro Rehabilitation conference, March 2015 on “Risk Factors for Health-Related Quality of Life in Pediatric Epileptic Patients – Observations from a Meta-Analysis”.
- Hussain N (2015), Oral presentation at 1stDHA Hematology Oncology Nursing Conference, April 2015 on “Social support need and expectations of mothers with leukemia affected children”.
- Hussain N (2015), Poster presentation at Pan Arab Interventional Radiology Society, March 2015 on “Echocardiographic aortic root dilatation in hypertensive subjects observations from a meta-analysis”
- Hussain N (2015), Poster presentation accepted at Emirates Gastroenterology and Hepatology conference, April 2015 on “The association of vitamin D levels with Advanced liver fibrosis and response to hepatitis C therapy”
- Hussain N (2014), Poster presentation at 2nd Gulf Chapter of the American Association of Clinical Endocrinologists, October 2014, “Haemoglobin variants affect HbA1C”
- Hussain N (2014), Poster presentation at 2nd Arab Society for Pediatric endocrinology and diabetes conference”, Nov 2014 “Cognitive decline in Type 2 diabetes: observations from a meta-analysis”
- Hussain N (2014), Poster presentation at World Heart Failure Society Congress, Dec 2014 “Heart failure management programs: observations from interventions used, a meta-analysis”
- ASSISTANT PROFESSOR |College of Pharmacy, Al Ain University of Science and Technology, Al Ain, UAE: August 2015 – current
- PHD STUDENT|College of Medicine and Health Sciences, UAE University: February 2011–May 2015
- INSTRUCTOR PHYSIOLOGY|Ras Al Khaimah Medical University, UAE: August 2006–February 2011
- MEDICAL OFFICER/LECTURER|Al Manal company, UAE: July 2005–July 2006
- TEACHING ASSISTANT|Baqai Medical university, Pakistan: 1998–2003
- HEALTH COLUMNIST|The Source magazine, Al Ain, UAE: 2013 – 2016
- RESIDENT MEDICAL OFFICER|Combined Military Hospital, Pakistan: 2003–2004
Human anatomy and histology, Physiology, Pathophysiology, Science and Life, Immunology, Biology
- Licensed medical physician, Pakistan medical and dental council, Pakistan
- American Society of Physiologists, USA
- American Physiology Society, USA
- Emirates Diabetes Society, UAE
- Emirates Medical Student Society, UAE
Levels of Vitamin D and Vitamin D Pathway Gene polymorphisms in adults: results from agriculture workers in Punjab, Pakistan
Published in: Progress in Nutrition
Jan 09, 2020
Background and aims: Worldwide low levels of vitamin D (< 30ng/dL) is prevalent and linked to bone disorders, diabetes and coronary heart disease. Deficiency in Vitamin D is a diagnostic challenge in asymptomatic individuals. The present study aimed to assess the environmental and also the genetic determinants affecting vitamin D deficiency in an asymptomatic rural agricultural population sample of Punjab province of Pakistan. Material and method: An interview based questionnaire and blood samples for measuring serum markers were obtained. These include calcium levels, parathyroid hormone and serum 25(OH) vitamin D. DNA was extracted from the blood samples for genotyping. Results: From 510 study participants, 435 (85.2%) individuals had < 30 ng/dL (low) of vitamin D. Males versus females had a unremarkable difference in the status of Vitamin D (61.3% vs 56.2%), (p = 0.134). When calcium levels were compared between the deficiency and insufficiency groups versus the vitamin D sufficiency group, no significant difference was observed (p = 0.526, 0.155 respectively). Consumption of single milk serving every day (250 ml) (p = 0.818) and sunlight exposure every day for more than 30 minutes (p = 0.579) also had non-significant associations with the estimated vitamin D levels. However, oral vitamin D supplementation was significantly associated (p = 0.024) with the vitamin D levels. Eight SNPs were studied and none showed any statistical significant association with observed vitamin D levels. Conclusions: We noted a considerable proportion of asymptomatic individuals from the rural population with low vitamin D levels. There appear to be multifactorial causes of deficiency in vitamin D and this burgeoning health issue requires further investigations.
The Clinical Significance of Statins - Macrolides Interaction: Comprehensive Review of In vivo, Case-reports and Population Studies, Therapeutics and Clinical Risk Management
Published in: Therapeutics and Clinical Risk Management
Aug 30, 2019
The objectives of this article were to review the mechanism and clinical significance of statins-macrolides interaction, determine which combination has the highest risk for the interaction, and identify key patients' risk factors for the interaction in relation to the development of muscle toxicity. A literature review was conducted in PubMed and Embase (1946 to December 2018) using combined terms: statins - as group and individual agents, macrolides - as group and individual agents, drug interaction, muscle toxicity, rhabdomyolysis, CYP3A4 inhibitors, and OAT1B inhibitors, with forward and backward citation tracking. Relevant English language in vivo studies in healthy volunteers, case reports, and population studies were included. The interaction between statins and macrolides depends on the type of statin and macrolide used. The mechanism of the interaction is due to macrolides' inhibition of CYP3A4 isoenzyme and OAT1B transporter causing increased exposure to statins. The correlation of this increased statin's exposure to the development of muscle toxicity could not be established, unless the patient had other risk factors such as advanced age, cardiovascular diseases, renal impairment, diabetes, and the concomitant use of other CYP3A4 inhibitors. Simvastatin, lovastatin, and to lesser extent atorvastatin are the statins most affected by this interaction. Rosuvastatin, fluvastatin, and pravastatin are not significantly affected by this interaction. Telithromycin, clarithromycin, and erythromycin are the most "offending" macrolides, while azithromycin appears to be safe to use with statins. This review presented a clear description of the clinical significance of this interaction in real practice. Also, it provided health care professionals with clear suggestions and recommendations on how to overcome this interaction. In conclusion, understanding the different characteristics of each statin and macrolide, as well as key patients' risk factors, will enable health care providers to utilize both groups effectively without compromising patient safety.
Published in: Australasian medical journal
May 03, 2018
Background: Diabetes mellitus(DM)is a leading cause of chronic kidney disease (CKD). Theantihyperglycemic treatment options for patients with Type 2 DM are limited because of safety and tolerability concerns. Aims: To retrospectively assess the effect of using Alogliptin; a dipeptidyl peptidase-4 inhibitor (DPP-4i) alongwith conventional gliclazide: a sulphonylurea (SU) on renal outcomes and glycaemiccontrol in T2DM patients with mildCKDand hypertension. Methods: A total of 76 patient records (38 males and 38 females) of patient ages 40–60 were analysed from the kidney unit at Punjab Care hospital, Lahore, Pakistan. All patients had a confirmed history of T2DM with mild CKD and established hypertension.Eligible patients were divided into two groups of 38 individuals each. Group SU received gliclazide monotherapy (SU) or Alogliptin (DPP-4i)+gliclazide (SU) add on therapy. All patients were followed up for 12 months.ResultsThe alogliptin (DPP-4i) plus gliclazide (SU) add on therapy group, in comparison to the group only receiving gliclazide (SU), showed a significant difference in eGFR values. The mean±SD GFR values post 12 months were 74.8±0.31(95%CI:74.8±0.09;74.7–74.9) and 76.1±0.25(95%CI: 76.1±0.08;76.0-76.2) for SU vs.SU+DPP-4i, respectively, with mean calculated effect size of 1.6,.HbA1c, 1,5 AG and ipid profile values have significantly changed(p<0.05) while blood pressure values showed no change. The mean±SD systolic blood pressure readings post 12 months for for SU vs.SU+DPP-4i were 131.4±10.4 (95% CI 131.4±3.3;128.1–134.7), and 131.8±9.9 (95%CI 131.8±3; 128.8–134.8), respectively. Conclusion: In the present study, patients using alogliptin in addition to sulfonyl urea showed improved glycaemic control and lipid profile without increased occurrence of hypoglycaemia. We concluded that, DPP-4iinhibitors are safe treatment options for patients with type 2 diabetes and mild degree of renal impairment. (7) (PDF) Effect of alogliptin on hypertensive chronic kidney disease patients with type 2 diabetes mellitus. Available from: https://www.researchgate.net/publication/323529444_Effect_of_alogliptin_on_hypertensive_chronic_kidney_disease_patients_with_type_2_diabetes_mellitus [accessed Dec 04 2018].
Safety Assessment of Neoadjuvant Pertuzumab Combined with Trastuzumab in Nonmetastatic HER2-Positive Breast Cancer in Postmenopausal Elderly Women of South Asia
Published in: International Journal of Breast Cancer
Apr 19, 2018
Abstract Aim. To evaluate the safety issues and adverse effects of using TCHP regimen (docetaxel, carboplatin, trastuzumab, and pertuzumab) versus TCP regimen (docetaxel, carboplatin, and trastuzumab) in older postmenopausal women with nonmetastatic HER2-positive breast cancer. HER2 overexpressed in 20–25% of breast cancer signals an aggressive form of breast cancer and is treated with trastuzumab and pertuzumab. Methods. The patient record database was accessed to identify all postmenopausal women in the Punjab Care hospital who were above 65 years old, with stages 1–3 HER2-positive breast cancer and treated with neoadjuvant TCHP and neoadjuvant TCP from 2013 till 2016. Results. In TCH-P group and TCH group, mild fatigue (34% versus 36%) and diarrhea (48% versus 49%) were most common toxicities. Fever in TCH-P group and TCH group (12% versus 13%) was common. Anorexia affected 21% and 16% of patients receiving TCH and TCHP regimen, respectively. Febrile neutropenia was higher in TCH-P group 13% (3/23) versus 4.5% (1/22) in TCH group. Also 27.2% (6/22) of TCH-P group was hospitalized for treatment related toxicities versus 21.7% (5/23) of TCH group. Conclusion. Comparing neoadjuvant TCP and neoadjuvant TCH-P showed TCH-P regimen had an acceptable toxicity profile. Severe cardiac dysfunction was not observed. Using TCH-P regimen can be considered as relatively safe therapeutic option for elderly postmenopausal women with nonmetastatic HER2-positive breast cancer.
Knowledge, attitude, and practice analysis of corticosteroid use among patients: A study based in the United Arab Emirates
Feb 09, 2017
Background: Corticosteroids (CS) have long been known as the most powerful of all known anti-inflammatory agents. Since their introduction in 1949, they have shown pivotal role in the treatment of various serious disorders such as autoimmune diseases, allergic processes, organ transplantation, rheumatologic, dermatological, pulmonary, hematological, ophthalmologic, gastrointestinal disorders, and others. Nevertheless, such massive clinical use does not come without risks, where prolonged use has been linked to several serious side effects. Therefore, careful consideration of precautions recommended for safe use of CS is of paramount importance. Aims and Objectives: To assess knowledge, attitude, and practice (KAP) analysis of the proper use of different dosage forms of CS medications in different sets of CS users in the United Arab Emirates (UAE), to explore the extent to which steroid outpatients were well engaged with medication proper use and safety-related behaviors. Materials and Methods: A structured interview-based methodology was adopted to assess the KAPs revolving around steroid usage in patients located in the UAE cities; Dubai, Sharjah, Ajman and Al Ain. Patients (n = 250) were selected randomly from different outpatient clinics all over the previously designated cities. The prepared interview questions were selected based on related therapeutics guidelines regarding aspects of proper patients CS use. Data were collected by well-trained researchers to conduct such interviews. SPSS V16.0 (SPSS Inc., Chicago, USA) was used for data analysis. Standard descriptive and analytical statistics were used to analyze the data. StudentÂ’s t-test was used to compare the mean difference of continuous variables. Results: Overall, our study showed poor KAP results among different UAE patients using different CS dosage forms. Conclusion: Despite the massive use of CS in almost every clinical settings and its inherent associated risks, patients still needs provisions for better education regarding their medication efficacy, safety, and proper use. By careful follow-up of proper CS use instructions, both patients and physicians would positively reach an optimized cost-effective therapeutic approach with much more improved benefit/risk ratio.