Rose Ghemrawi, Ph.D

Assistant Professor

Abu Dhabi Campus

+ 971 2 4444270

rose.ghemrawi@aau.ac.ae

Education

Post-doctoral fellow, Dr. Sarah Kimmins laboratory, McGill University, Montreal, Canada, August 2016- August 2017.

Post-doctoral fellow, ‘Nutrition, Genetics and Environmental Risk Exposure’ laboratory, France, October 2013- April 2016.

Ph.D. in Life and Health Sciences, Lorraine University, France.

M.SC Biochemistry, Biology and Health, Lorraine University, France.

B.SC. Biochemistry, Lebanese University, Lebanon.

Research Interests

Fertility, Cardiovascular diseases, Neurodegenerative diseases, Endoplasmic reticulum stress, Inherited defects of B12 metabolism, RNA binding proteins, Epigenetics.

Selected Publications

  • Ghemrawi R*Khair MEndoplasmic Reticulum stress and Unfolded Protein Response in neurodegenerative diseases. Int J Mol Sci. 2020 Aug 25;21(17): E6127 *Corresponding author
  • Ghemrawi R, Arnold C, Battaglia-Hsu SF, Pourie G, Bassila C, Charif R, Wiedemann A, Flayac J, Robert A, Dreumont N, Feillet F, Gueant JL, Coelho D. SIRT1 activation rescues the mislocalization of RNA-binding proteins and cognitive defects induces by inherited cobalamin disorders. Metabolism, 2019;101:153992
  • Ghemrawi R, Battaglia-Hsu SF, Arnold C. Endoplasmic Reticulum stress in metabolic disorders. Cells, 2018; 7(6): 63
  • Battaglia-Hsu SF*, Ghemrawi R*, Dreumont N, Coelho D, Sequeira JM, Ndiongue M, Houlgatte R, Helle D, Alberto JM, Umoret R, Jung M, Quadros EV, Gueant JL. Cobalamin controls mRNA transport through its influence on methylation/phosphorylation of RNA binding proteins in brain. Nucleic Acids Res, 2018; 46(15): 7844–7857 *Equal Contribution
  • Bassila C, Ghemrawi R, Flayac J, Froese DS, Baumgartner MR, Gueant JL, Coelho D. Methionine synthase and methionine synthase reductase interact with  MMACHC  and with MMADHC. Biochim Biophys Acta, 2017; 1863(1):103-112
  • Feigerlova E, Demarquet L*, Melhem M*, Ghemrawi R*, Battaglia-Hsu SF, Ewu E, Alberto JM, Weryha G, Gueant JL. Methyl donor deficiency impairs bone development via peroxisome proliferator-activated receptor-γ coactivator-1α-dependent vitamin D receptor pathway. Faseb J, 2016; 30(10):3598-3612 *Equal Contribution
  • Ghemrawi R, Pooya S, Lorentz S, Gauchotte G, Arnold C, Gueant  JL,  Battaglia-Hsu SF. Decreased vitamin B12 availability induces ER stress through impaired SIRT1- deacetylation of HSF1. Cell Death and Dis, 2013; 4:e553

Book Chapters:

  • Al Sorakhy M, Ghemrawi R. Legacy and innovative treatment: Projected modalities for antimicrobial intervention, Microbiomics. 2019

Teaching Courses

Biochemistry, Pharmacogenomics, Microbiology and Immunology, Biology, Science and Life, Organic Chemistry lab, Analytical Chemistry lab.

 

Memberships

  • Member of the International DOHaD Society.
  • Member of the Canadian DOHaD Society.
  • Member of the Organization for the Study of Sex Differences.