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The Clinical Significance of Statins - Macrolides Interaction: Comprehensive Review of In vivo, Case-reports and Population Studies, Therapeutics and Clinical Risk Management

Published in: Therapeutics and Clinical Risk Management

Aug 30, 2019

• Abu Mellal A Hussain N Said ASA

The objectives of this article were to review the mechanism and clinical significance of statins-macrolides interaction, determine which combination has the highest risk for the interaction, and identify key patients' risk factors for the interaction in relation to the development of muscle toxicity. A literature review was conducted in PubMed and Embase (1946 to December 2018) using combined terms: statins - as group and individual agents, macrolides - as group and individual agents, drug inte...


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