Biography

More than 17 years of experience in research and teaching in the field of development of dosage forms, especially nanomedicines and their interactions with the biological system for the treatment of chronic inflammatory diseases.
Design and validate the cell co-culture model for the treatment of lung cancer. Experience in performing various in vitro and in vivo techniques including cell culturing, cell viability assay, western blotting, ELISA and PCR. You will also work with flow cytometry and confocal microscope. Moderate experience working with atomic force microscopy, X-ray diffraction, FT-IR and microcalorimetry.
Develop the physiologically based pharmacokinetic model (PBPK) for a few drugs. Interoperate the ADMET properties and the pharmacokinetic compartment properties of drugs. Simulate the possible drug-drug interactions and validate the plasma concentration-time curve using multiple doses and dosage forms.

 

Education

Doctor of Philosophy (Ph.D.) (Pharmaceutical Sciences) University of Alberta, Edmonton, Alberta, Canada.

Master of Philosophy, (Pharmaceutics) The Islamia University of Bahawalpur, Pakistan.

Bachelor of Pharmacy, The Islamia University of Bahawalpur, Pakistan.

Research Interests

• Synthesis and In Vitro and In Vivo Characterization of Nanoparticles.
• Target Drug Delivery of Nanoparticles and its Impact on Cell Models.
• Developing Co-Culture models for Cancer Cells and Macrophages.
• PBPK/PD modeling, Drug Drug Interaction, Population PK and IVIVC using Gastroplus Simulation Software.

Selected Publications

 

• Hamid Saeed Shah, Sumera Zaib, Faisal Usman, Muhammad Sarfraz, Rabia Faiz, Saira Abdul Rehman, Azmat Ali Khan, Amer M Alanazi, Riffat Khan, Usman Nasrullah, Imran Nazir. Synthesis, characterization, pharmacological and computational evaluation of hyaluronic acid modified chebulinic acid encapsulated chitosan nanocomposite for cancer therapy. Int. J. Biol. Macromol. April. 2024 https://doi.org/10.1016/j.ijbiomac.2024.130160
• Farid Mostafaei, Salar Hemmati, Hadi Valizadeh, Mohammad Mahmoudian, Muhammad Sarfraz, Mahdieh Abdi, Shukoofeh Torabi, Behzad Baradaran, Massoud Vosough, Parvin Zakeri-Milani. Enhanced intracellular accumulation and cytotoxicity of bortezomib against liver cancer cells using N-stearyl lactobionamide surface modified solid lipid nanoparticles. Int.J.Pharm. 649, P: 123635, January 2024 https://doi.org/10.1016/j.ijpharm.2023.123635
• Muhammad Sarfraz, M Afroz Bakht, Mohammed Sanad Alshammari, Mohammad Alrofaidi, Abdullah R Alzahrani, Lina Eltaib, Syed Mohammed Basheeruddin Asdaq, Faris F Aba Alkhayl, Abida, Mohd Imran. Beyond traditional medications: exploring novel and potential inhibitors of trypanothione reductase (LmTr) of Leishmania parasites. J. Biomol. Struct. Dyn. December 2023 https://doi.org/10.1080/07391102.2023.2300062
• Muhammad Sarfraz, Kanwal Shabbir, Qazi Adnan, Haji Muhammad Shoaib Khan, Jafir Hussain Shirazi, Hamna Sabir, Nimrah Mehmood, Yousef A Bin Jardan, Kifayat Ullah Khan, Abdul Basit. Fabrication, organoleptic evaluation and in vitro characterization of cream loaded with Carica papaya seed extract. J.Cosmet. Dermatol. December 2023 https://doi.org/10.1111/jocd.16066
• Muhammad Sarfraz*, Ume Ruqia Tulain^,, Alia Erum, Nadia Shamshad Malik, Arshad Mahmood, Sumaira, Sidra Aslam, Mansur Abdullah Sandhu and Muhammad Tayyab Cydonia oblonga-Seed-Mucilage-Based pH-Sensitive Graft Copolymer for Controlled Drug Delivery In Vitro and in Vivo Evaluation. Pharmaceutics Vol 15, 2445, P-1-21 October 2023 https://doi.org/10.3390/pharmaceutics15102445
• Muhammad Sarfraz*, Abida Khan, Gaber El-Saber Batiha, Muhammad Furqan Akhtar, Ammara Saleem, Basiru Olaitan Ajiboye, Mehnaz Kamal, Abuzer Ali, Nawaf M. Alotaibi , Shams Aaghaz, Muhammad Irfan Siddique and Mohd Imran. Nanotechnology-Based Drug Delivery Approaches of Mangiferin: Promises, Reality and Challenges in Cancer Chemotherapy. Cancers Vol 15, 4194, P-1-21 August 2023 https://doi.org/10.3390/cancers15164194
• Muhammad Sarfraz, Rabia Iqbal, Kifayat Ullah Khan, Muhammad Usman Minhas. Carbopol Based Hydrogels for ITOPRIDE Hydrochloride Delivery; Synthesis, Characterization and Comparative Assessment with Various Monomers. J. Funct. BIomater. 13, 295, P:2-21, December, 2022 https://doi.org/10.3390/jfb13040295
  
• Mohammad Feyzizadeh, Ashkan Barfar, Zeinab Nouri, Muhammad Sarfraz, Parvin Zakeri-Milani, Hadi Valizadeh. Overcoming multidrug resistance through targeting ABC transporters: lessons for drug discovery. Expert Opin. Drug Discov. Page:1-15, September 2022  https://doi.org/10.1080/17460441.2022.2112666
• Muhammad Sarfraz, Shaista Qamar, Masood Ur Rehman, Muhammad Azam Tahir, Muhammad Ijaz, Anam Ahsan, Mulazim Hussain Asim, Imran Nazir. Nano-Formulation Based Intravesical Drug Delivery Systems: An Overview of Versatile Approaches to Improve Urinary Bladder Diseases. Pharmaceutics Vol: 14 (9) 1909. September 2022 https://doi.org/10.3390/pharmaceutics14091909
• Solmaz Mojarad-Jabali, Somayeh Mahdinloo, Masoud Farshbaf, Muhammad Sarfraz, Yousef Fatahi, Fatemeh Atyabi, Hadi Valizadeh. Transferrin receptor-mediated liposomal drug delivery: recent trends in targeted therapy of cancer. Expert Opin. Drug Deliv. Page1-21 July 2022 https://doi.org/10.1080/17425247.2022.2083106
• Fahimeh Zahednezhad, Javid Shahbazi Mojarrad, Parvin Zakeri-Milani, Behzad Baradaran, Mohammad Mahmoudian, Muhammad Sarfraz & Hadi Valizadeh. Surface modification with cholesteryl acetyl carnitine, a novel cationic agent, elevates cancer cell uptake of the PEGylated liposomes. Int. J. Pharm. Vol 609, 121148, November 2021 https://doi.org/10.1016/j.ijpharm.2021.121148
• M Rashid, Muhammad Sarfraz, M Arfat, A Hussain, N Abbas, K Hussain, NI Bukhari. Prediction of pharmacokinetic parameters and dose of pregabalin gastroretentive formulation in healthy adults, healthy pediatrics and renal-impaired geriatrics. J Drug Deliv Sci Technol 63, 102548, October 2021 https://doi.org/10.1016/j.jddst.2021.102548

Conferences

• Mosab Arafat, Muhammad Sarfraz, Cathrin Kirchhoefer, Raimar Löbenberg R. Studying vesicles membrane stability of nanotransfersomes containing bile salts using calcein as a marker for stability. The Americana Association of Pharmaceutical Scientists Journal. AAPS Annual Meeting and Exposition. November 3-6, 2019. San Antonio, Texas, USA 
• Mosab Arafat, C. Kirchhoefer, Sarfraz M, Löbenberg R. Study the Effect of Physiological Fluid on Vesicles Membrane Stability of Liposomes containing Bile Salts using Calcein as a Marker for Vesicles Leakage. The Americana Association of Pharmaceutical Scientists Journal. AAPS Annual Meeting and Exposition. November 4-7, 2018. Washington DC, USA.
• Mosab Arafat, Kirchhoefer C, Mikov M, Sarfraz M, Löebenberg R. The enhancement of the poor oral bioavailability of cefotaxime sodium using nano-mixed micelles formulation. Canadian Society for Pharmaceutical Sciences. 2018 CSPS Annual Symposium. May 22 – 25, 2018. Toronto, Canada.
• Khalid N, Sarfraz M, Mosab Arafat, Akhtar M, Rahman N, Löebenberg R. Nano-sized Droplets of Self-emulsifying System for Enhancing Oral Bioavailability of Etoposide in Rats.Canadian Society for Pharmaceutical Sciences. 2018 CSPS Annual Symposium. May 22 – 25, 2018. Toronto, Canada.
• Mosab Arafat,  Sarfraz M, Kirchhoefer C, Mikov M., Löbenberg R. Dual Effect of Bile Salts in Nanocarriers: Counteracting Gastrointestinal Lysis and Enhancing The Oral Bioavailability of BCS Class III Drug. The Americana Association of Pharmaceutical Scientists Journal. AAPS Annual Meeting and Exposition. November 12-15, 2017. San Diego, California, USA.

Teaching Courses

• Pharmaceutics -I (BSc.)
• Biopharmaceutics and Pharmacokinetic (BSc.)
• Medication Dispensing and Drug Distribution System. (BSc.)
• Industrial Pharmacy Training (BSc.)
• Advanced Biopharmaceutics and Pharmacokintics (MSc.)
• Adavanced Drug Delivery (MSc.)
• Drug Development and Regulatory Affairs (MSc.)

 

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all.

This person’s work contributes towards the following SDG(s):

  

Memberships

• Pharmacy Council of Pakistan.
• Canadian Society of Pharmaceutical Sciences (CSPS), Canada.
• American Association Pharmaceutical Scientist. (AAPS) USA.